Polysorbate 20#CAS9005-64-5
Polysorbate 20#CAS9005-64-5
Tween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil. It is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Tween 20 is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading. Besides, Tween 20 also has applications in food production as a common food grade additive which are found in many consumables on the market today. It can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.
Polysorbate 20 is a hydrophilic nonionic surfactant generally used as emulsifiers, dispersing agent and solubilizer.
Application of Polysorbate 20
Used for solubilizing membrane proteins during isolation and purification.Polysorbate 20 is used as a wetting agent in flavored mouth drops. It acts as a washing agent in Western blots and ELISAs and prevents antibody binding. It is a solubilizing agent of membrane proteins. In pharmaceutical chemistry, it is used as an excipient to stabilize emulsions and suspensions. Further, it is used as a dispersing agent, stabilizer, lubricator and also used in creams, salves, ointments, protective creams, balms, pomades, lipsticks, mascaras and glosses.
polysorbate 20 is a solubilizer, emulsifier, viscosity modifier, and stabilizer of essential oils in water.
| Polysorbate 20 Chemical Properties |
| Melting point | -14 °C |
| Boiling point | > 100 °C (212 °F; 373 K) |
| density | 1.1 g/mL (approximate) |
| vapor pressure | <1.4 hPa (20 °C) |
| FEMA | 2915 | POLYSORBATE 20 |
| refractive index | 1.47 |
| Fp | 110 °C (230 °F; 383 K) |
| storage temp. | Store below +30°C. |
| solubility | 100 g/L |
| form | Clear viscous liquid |
| color | yellow to yellow-green |
| Specific Gravity | 1.090~1.130 (20/20℃) |
| PH | 6-8 (50g/l, H2O, 20℃) |
| PH Range | 7 |
| Odor | mild alcohol odor |
| Odor Type | alcoholic |
| biological source | synthetic |
| Water Solubility | 100 g/L |
| Hydrophilic-Lipophilic Balance (HLB) | 16.7 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | SURFACTANT - EMULSIFYING SURFACTANT - CLEANSING |
| Cosmetic Ingredient Review (CIR) | Polysorbate 20 (9005-64-5) |
| InChI | 1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3 |
| InChIKey | HMFKFHLTUCJZJO-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO |
| EPA Substance Registry System | Polysorbate 20 (9005-64-5) |
| Absorption | = 0.025 at 254nm at 0.05% (w/v) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 22-36/37/38-37/38-41 |
| Safety Statements | 24/25-36/37/39-36-26 |
| WGK Germany | 1 |
| RTECS | TR7400000 |
| F | 10-23 |
| TSCA | TSCA listed |
| HS Code | 34021300 |
| Storage Class | 10 - Combustible liquids |
| Hazardous Substances Data | 9005-64-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 38900 mg/kg |
Fact Factory and Equipment Show
