Myristic acid #CAS544-63-8
Myristic acid appears as white to yellowish white solid, sometimes appearing as shiny crystalline solid, or white to yellowish white powder. It has a relative density of 0.8739 (80 ℃), melting point of 54.5 ℃ and the boiling point of 326.2 ℃. Its refractive index (nD60) is 1.4310. It is not soluble in water but soluble in ethanol, ether and chloroform. Myristin contains about 70% to 80% while other kinds of coconut oil, palm kernel oil also contain it.
Applicaion of Myristic acid
Myristic Acid is a saturated fatty acid obtained from nutmeg，coconut oil and other fats. it has poor water solubility but is soluble in alcohol, chloro- form, and ether. it is used as a lubricant, binder, and defoaming agent.Myristic acid is a 14-carbon saturated (14:0) fatty acid. In vivo, it is commonly added covalently to the N-terminus of proteins in a co-translational process termed N-myristoylation. In addition, there are examples where N-myristoylation occurs post-translationally, when a hidden myristoylation pattern is exposed.
Myristic acid is a saturated fatty acid widely used in multiple industries. It serves as an important raw material for synthesizing various surfactants and emulsifiers, which are core components for soaps, household detergents and industrial cleaning agents. It can react with metal compounds to produce metal myristates, which are commonly used as heat stabilizers, lubricants and release agents for plastic and rubber products. After esterification with different alcohols, it forms myristate esters, which are widely used as emollients, thickeners and skin-conditioning agents in cosmetics and personal care products. It is frequently added into creams, lotions, facial cleansers, shaving products and makeup formulas to adjust product texture, improve emulsification stability and enhance skin feel. It can also be used as a processing aid in rubber industry to boost filler dispersion and improve molding performance. Food-grade myristic acid can be applied as food additives and coating agents. In pharmaceutical field, it is used to prepare pharmaceutical intermediates, ointment substrates and sustained-release excipients. Moreover, it is adopted in the production of lubricating greases, flotation agents and textile finishing auxiliaries.
| Myristic acid Chemical Properties |
| Melting point | 52-54 °C(lit.) |
| Boiling point | 250 °C100 mm Hg(lit.) |
| density | 0.862 |
| vapor pressure | <0.01 hPa (20 °C) |
| FEMA | 2764 | MYRISTIC ACID |
| refractive index | nD60 1.4305; nD70 1.4273 |
| Fp | >230 °F |
| storage temp. | room temp |
| solubility | 1.07mg/l |
| pka | 4.78±0.10(Predicted) |
| form | Flakes, Powder, Chunks or Crystalline Mass |
| color | White |
| Odor | at 100.00 %. waxy fatty soapy coconut |
| Odor Type | waxy |
| biological source | synthetic |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| Specific Heat Capacity | Cp(crystal): 1.89 J/(g·K), at 25℃ |
| JECFA Number | 113 |
| Merck | 14,6333 |
| BRN | 508624 |
| Henry's Law Constant | 2.0×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Stability: | Stable. Incompatible with strong oxidizing agents, bases. |
| Major Application | flavors and fragrances |
| Cosmetics Ingredients Functions | SURFACTANT - CLEANSING PERFUMING OPACIFYING FRAGRANCE |
| Cosmetic Ingredient Review (CIR) | Myristic acid (544-63-8) |
| InChI | 1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16) |
| InChIKey | TUNFSRHWOTWDNC-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCC(O)=O |
| LogP | 5.79 |
| CAS DataBase Reference | 544-63-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Tetradecanoic acid(544-63-8) |
| EPA Substance Registry System | Myristic acid (544-63-8) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-38 |
| Safety Statements | 24/25 |
| WGK Germany | - |
| RTECS | QH4375000 |
| TSCA | TSCA listed |
| HS Code | 2915900090 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 544-63-8(Hazardous Substances Data) |
| Toxicity | LD50 i.v. in mice: 432.6 mg/kg (Or, Wretlind) |
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