Choline chloride #CAS：67-48-1
CAS Number:67-48-1
Chemical Formula:C5H14ClNO
Synonyms:
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
Choline chloride >=97.0% (AT)
Choline chloride, 99% 50GR
Appearance:White
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Choline chloride #CAS：67-48-1
Choline is an indispensible fundamental component in humans and animal body, often referred to as B vitamins or vitamin B4, and is a necessary low-molecule organic compound for maintaining physiological function off animal body. It can be synthesized inside animal body but still often need to be supplied to dietary and is a kind of vitamin in maximal usage amount. Inside animal cells, it can be used to adjust the in vivo metabolism and conversion of fats, preventing the fat deposition and tissue degeneration of liver and kidney, and then promote the regeneration of amino acids, enhance utilization of amino acids as well as save some part of methionine.Choline chloride is the most commonly used as well as most economical form of synthetic choline and is a water soluble vitamin, and is the component for constituting of acetylcholine, lecithin, and nerve phospholipids of biological tissue. Moreover, it can save methionine and is an important material required for livestock, poultry, and fish. Inside animal body, it can be used for adjusting in vivo metabolism and conversion of fats and can prevent the deposition in liver and related tissue degeneration. As a methyl donor, it can promote the re-formation of amino acids and improve the utilization of amino acids. It is mainly used as an additive for being mixing into the animal feed. During the exact usage process, in addition to prevent moisture deliquescence, you should also note that all kind of feeds usually take the addition of choline chloride as the last step. Because of its destruction effects on other vitamins, especially its rapid destruction on vitamin A, D, K in the presence of metal elements, multi-dimensional formulation should not include choline. Daily feed supplied with it should be used as soon as possible after the addition. Tests have showed that choline chloride is especially important for chicken poultry. Its synthetic amino acids and lecithin can be delivered to various locations inside chicken bodies, being able to prevent the fat deposition in the liver and kidney and accelerate the growth of chickens and increase egg production and hatchability.
Application of Choline chloride
Choline chloride is an animal feed additive, classified as a water-soluble B-vitamin that increases animal growth. ChCl is added exogenously to feedstocks because it plays an essential role in fat transport and metabolism and protects cell membrane structure. It can be supplied to tissue culture media and animal feed additives and used as a clinical anti-fatty liver agent.It can be used to treat fatty liver and cirrhosis. It can also be used as a feed additive, stimulating the ovaries to give birth to more eggs and farrow. It can also facilitate the weight-gaining process of livestock, fish, etc.
Choline chloride is effective in preventing and treating fat deposition and tissue degeneration in livestock and poultry organs. It can also promote the absorption and synthesis of amino acids. Moreover, it can enhance livestock's physical fitness and disease resistance, promote their growth and development, and improve poultry laying rate. The usage amount is 1-2 g/kg.
As a kind of feed additive, choline chloride has the following physiological effects: it can prevent the accumulation of fat in the liver and the kidney and tissue degeneration; it can promote the recombination of amino acids; it can improve the utilization efficiency of amino acids, especially the essential amino acid methionine in vivo. In Japan, 98% of the applied choline chloride is used as feed additives for chickens, pigs, cattle, fish, and other animals. Most of them have been processed into powder; the preparation process of 50% powder is that: first, add an appropriate excipient of specific particle size into the mixer prepared by previously adding an appropriate particle size of the excipient, and then add dropwise of aqueous solution of choline chloride, after mixing, drying to derive it. Some powder products are also blended with vitamins, minerals, and drugs. Choline chloride is a vitamin B-class drug that can be used for the treatment of hepatitis, liver function degradation, early cirrhosis, and pernicious anemia.
It is a precursor of acetylcholine and is a methyl donor in various metabolic processes and lipid metabolism.
| Choline chloride Chemical Properties |
| Melting point | 302-305 °C (dec.) (lit.) |
| density | 1.0238 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| FEMA | 4500 | Choline chloride (Also Includes Choline) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: 1 M, clear, colorless |
| form | Adhering Crystals |
| color | White |
| Odor | sl. odor of trimethylamine |
| PH | 5.0-7.5 (25℃, 1M in H2O) |
| biological source | synthetic (organic) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| λmax | λ: 260 nm Amax: 0.015 λ: 280 nm Amax: 0.010 |
| Merck | 14,2206 |
| JECFA Number | 2003 |
| BRN | 3563126 |
| Stability: | Stable. Incompatible with strong oxidizing agents, moisture. Store under a dry atmosphere. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING HUMECTANT |
| Cosmetic Ingredient Review (CIR) | Choline chloride (67-48-1) |
| InChI | 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1 |
| InChIKey | SGMZJAMFUVOLNK-UHFFFAOYSA-M |
| SMILES | [Cl-].C[N+](C)(C)CCO |
| LogP | -3.70 |
| CAS DataBase Reference | 67-48-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Choline chloride(67-48-1) |
| EPA Substance Registry System | Choline chloride (67-48-1) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 1 |
| RTECS | KH2975000 |
| F | 3-9 |
| Autoignition Temperature | 355°C |
| TSCA | TSCA listed |
| HS Code | 29212900 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 67-48-1(Hazardous Substances Data) |
| Toxicity | LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish) |
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